Hyperoxia in head injury: therapeutic tool?

Retracted: Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

Effects of normobaric hyperoxia pretreatment on ischemia-reperfusion injury in regional ischemia model of isolated rat heart

Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts w...

Asiaticoside attenuates hyperoxia-induced lung injury in vitro andin vivo

Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...

The link between hyperoxia, delayed cerebral ischaemia and poor outcome after aneurysmal SAH: association or therapeutic endeavour.

In this study, Jeon et al assess the association between exposure to hyperoxia in ventilated patients following aneurysmal subarachnoid haemorrhage (SAH) and both delayed cerebral ischaemia (DCI) and functional outcome. Prospective data from an observational cohort of patients with available partial pressure of oxygen (PaO2) was retrospectively assessed. Hyperoxia was defined as the highest qua...